Nutrition Management of mechanically ventilated patients with COVID-19
Know more about the Nutrition Management of mechanically ventilated patients suffering from COVID-19View article
During the Lipids in Parenteral Nutrition Summit, a group of internationally renowned experts in clinical nutrition, lipid metabolism, and pharmacology from five continents convened to assess the state of knowledge and develop consensus statements for the use of intravenous lipid emulsions (ILEs) in different patient populations and clinical settings. The consensus statements were developed to offer healthcare professionals practical guidance on common questions regarding the provision of ILEs in parenteral nutrition (PN).[i]
The fatty-acid composition of the lipid emulsions affects the inflammatory process
Figure 1: The biphasic immuno-inflammatory response to a traumatic insult, characterized by increased generation of inflammatory mediators and then a shift towards an anti-inflammatory immunosuppressed state, may be further worsened by a preponderance of ω-6 fatty acids but improved by the presence of ω-3 fatty acids DHA and EPA. DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; HLA, human leukocyte antigen; NFκB, nuclear factor κ B.
Fish oil containing ILEs may lead to improved clinical outcomes in hospitalized adults
The expert panel states that there is sufficient evidence to recommend the use of ILEs containing omega-3 PUFAs at a dosage of 0.1-0.2 g fish oil/kg/d as part of the ILE both for critically ill as well as in surgical patients.[iii]
The most recent systematic review and meta-analysis from Pradelli et al.Topics[iv] includes 49 randomized controlled trials (RCTs) with intervention and control groups (n=3,641 patients) on omega-3 fatty acid containing vs. standard PN (non-omega-3 fatty acid containing) in adult hospitalized patients. Investigating clinical efficacy and laboratory parameter outcomes, the authors show:
Therefore, omega-3 fatty acid containing PN is associated with statistically and clinically significant advantages on clinical outcomes.